According to Talmudic sources, a great wave that impacted Caesarea and Yavneh, reached as far as Rome, and was caused by an earthquake that destroyed Antioch occurred on December 13, 115 C.E. This study has shown that the coastal structures of Caesarea, Israel were struck by a tsunami wave sometime in the 1st or 2nd century C.E. The wave left a deposit of shell, coarse sand, pebble, and pottery outside of the harbor. Taxonomic identification of the shell and sedimentological analysis has identified the deposit as tsunamigenic. The tsunamigenic horizon has been characterized by a bi-modal distribution. The lower portion has been characterized primarily of shell fragments and rounded pebbles while the upper portion contains a greater percentage of whole shells lying in a convex-up position. This has been interpreted as the result of shells deposited after being transported from their living position, carried in suspension within the tsunami wave and broken after contacting the harbor structure. The presence of broken shell and the thickness of the deposit suggest that the force of the wave was greater than that of typical large storm surges. Text has been used in many earthquake and tsunami catalogues to identify tsunamis in the 1st century B.C.E.- 3rd C.E. on the coast of Israel, however, none of the tsunami events have been confirmed with physical evidence. Radiocarbon-AMS, OSL and ceramic dates suggest that this tsunamigenic deposit could correlate with the tsunami of December 13, 115 C.E.